Accession Number:

AD1146200

Title:

Defining and Therapeutically Targeting the Immunological Landscape of SF3B1-Mutant Breast Cancer

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA

Personal Author(s):

Report Date:

2021-07-01

Pagination or Media Count:

50

Abstract:

The core RNA splicing factor SF3B1 is recurrently mutated in breast cancer. These mutations occur as focal missense changes that alter SF3B1s normal role in RNA splicing. As a consequence, cells bearing these recurrent changes exhibit changes in splicing affecting hundreds of genes. We found that these recurrent splicing changes in breast cancers bearing SF3B1 mutations resulted in the widespread production of abnormal mRNAs that encode novel proteins, which could result in the generation of neoepitopes that are recognizable by the immune system. We are therefore testing the hypothesis that splicing errors in breast cancer give rise to novel antigens that may facilitate recognition of tumor cells by the immune system.

Descriptors:

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

[A, Approved For Public Release]