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Targeted Nutritional Approach to Improve Muscle Function and Physical Activity by Restoring Metabolic Deregulations During Recovery from Sepsis

Descriptive Note:

[Technical Report, Annual Report]

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Purpose The major goal to the project is to test the hypothesis that a unique formulation based on EAA will improve physical activity, and involuntary isometric skeletal muscle strength faster during the recovery of a sepsis event. Scope The proposed study in a catheterized pig model recovering from sepsis is innovative because, a the targeted nutritional supplementation is a novel approach to attenuate tissue breakdown in sepsis and improve functional outcome and restore muscle mass, b it provides insights into sepsis-induced severe tissue breakdown and physical outcome. The use of innovative, stable tracer methodology to measure metabolic fluxes within and across muscle, enables quantification of all metabolic endpoints. The results of the proposed study will have a positive impact by providing the basis to develop novel cost-effective nutritional approaches for patients recovering from sepsis to improve recovery and rehabilitation. It has a strong justification because of its rapid translation into clinical application. Achievement of year 1 Concerning the pig studies we obtained IACUC approval. We implemented logistics for monitoring physical activity and muscle strength measurement buying testing equipment and other surgeryanimal carepharmaceutical compounding analytical related preparations. Started with the animal studies and validated the approach and trained new personnel. No changes needed to be made concerning the approach.


Subject Categories:

  • Stress Physiology
  • Food, Food Service and Nutrition

Distribution Statement:

[A, Approved For Public Release]