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MRI Volumetrics for Risk Stratification of Vision Loss in Optic Pathway Gliomas Secondary to NF1

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[Technical Report, Annual Report]

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Our overall objective is to develop and validate a novel quantitative MRI analysis software application that will enable 1 identifying children who are at the greatest risk for vision loss from their NF1-OPG and 2 making treatment decisions based on accurate evaluation of disease progression and response to therapy. Over the past year, we have completed Tasks 1, 2 and 3 Aim 1 and Task 4-5 Aim 2 while making good progression on the remaining tasks and Aim 3 as listed in the SOW. Accurate MRI-base volumetric measurements have been achieved in the CHOP and CNHS data cohorts. We have performed analysis of longitudinal changes in tumor volume and shape and are actively working on identifying the optimal set of MRI features that predict clinical outcomes Task 6, Aim 2. Subject enrollment in the International NF1-OPG Natural History study is on track with over 185 subjects enrolled and 103 having completed the 1-year outcome, confirming we will have a complete data set to finish Aim 3 as planned. We have not made any significant changes to our study plan.


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  • Medicine and Medical Research

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[A, Approved For Public Release]