Accession Number:

AD1141231

Title:

Ethnic Disparity of Mitochondrial Peptides and Prostate Cancer Risk

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

University of Southern California

Report Date:

2021-01-01

Pagination or Media Count:

21

Abstract:

Mitochondrial-dysfunction is associated with prostate-cancer PC. We hypothesized that differences in MDP-expression levels contributes to the elevated-risk of PC in Black men. Our project is testing the potential of MDPs as biomarkers for PC risk, both as circulating pre-diagnostic biomarkers and as surrogate mitochondrial genetic risk indicators in a group of Black and Whitemen with and without PC. Our Specific Aims include 1 To confirm the association between SHLP2 levels and prostate cancer risk 2 to determine the association between additional plasma MDPs and prostate cancer risk among Black and White men in a newly enrolled population and 3 to determine the contribution of mitochondrial versus nuclear genetic-race, relative to self-reported-race, to the MDP-PC-risk connection. We have succeeded in enrolling substantial numbers of patients of both ethnicities. Our data confirms that MDP levels are generally lower in plasma of PC patients. We identified novel ethnic-specific mtDNA variants associated with PC. We showed that mtDNAcn is also associated with PC risk. This study is the first to study racial differences in MDP levels and their effect on PC. MDP levels and mitochondrial genetic origin may serve as diagnostic biomarkers of PC. Moreover, this study may set the stage for future mitochondrial-related interventions in minority populations.

Subject Categories:

  • Medicine and Medical Research
  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]