Accession Number:



Evaluation of the Effects of High Level Overpressure (8+psi) on Cognitive Performance, Brain Blood Biomarkers and Symptom Reporting

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

The Geneva Foundation

Personal Author(s):

Report Date:


Pagination or Media Count:



This is a multi-site observational study of military and law enforcement personnel who are exposed to overpressure OP where data is collected in conjunction with occupational training exercises. The studys primary purpose is to characterize a variety of weapon systemsenvironments OP, impulse, acoustics and measure effects neurocognitive, biomarkers, symptom reporting, etc. immediately after OP exposure 5 minandor at end of training day i.e., acute effects. 2 data collections took place n1 15, n2 15 at2 different sites. Sensor orientation, position, and distance from the blast source are necessary details for sufficiently interpreting occupational blast exposure. Blast exposure levels are affected by a variety of factors tactical methods and weapon suppressors may mitigate overpressure and acoustic exposures, whereas helmet shape may increase exposure due to an under-wash effect. Overpressure and acoustic exposure levels measured in a low overpressure blast environment were associated with neurocognitive deficits. Changes were identified in blood-based biomarkers targeted proteins, DNA methylation after repeated blast overpressure exposure.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

[A, Approved For Public Release]