Accession Number:

AD1132253

Title:

TRACK-TBI Precision Medicine - Pathomechanistic Classification of Traumatic Brain Injury: The Bridge to Targeted Therapies

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

University of California, San Francisco

Personal Author(s):

• Manley , Geoffrey T.
• Markowitz, Amy J.
• Fabian, Brian

Report Date:

2020-10-01

Pagination or Media Count:

127

Abstract:

TRACK-TBI Precision Medicine utilizes the rich TRACK-TBI dataset to validate biomarkers of diffuse axonal injury DAI, microvascular injury MVI, and neuro-inflammation using advanced blood-based assay platforms and MRI sequences. The project will validate early and ultra-early blood-based and imaging biomarkers of DAI, MVI, and neuro-inflammation and will conduct a multicenter, double-blind, placebo-controlled exploratory clinical trial comparing the impact of cyclosporine A on blood-based and imaging biomarkers of DAI and neuro-inflammation in moderatesevere TBI patients.

Descriptors:

• health services
• medical personnel
• brain injuries
• neuroimaging
• x-ray computed tomography
• cardiovascular system
• therapy
• mobile phones
• cognitive impairment
• vascular system injuries
• brain
• proteins
• statistical analysis
• traumatic stress disorder
• chemistry
• demography
• employment
• magnetic resonance
• patient care
• personnel management

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology
• Biochemistry

Distribution Statement:

[A, Approved For Public Release]