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Novel Noninvasive Methods of Intracranial Pressure and Cerebrovascular Autoregulation Assessment: Seeing the Brain Through the Eyes

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

University of Michigan, Michigan Center for Integrative Research in Critical Care

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Traumatic brain injury TBI plays a major role in approximately 30 of injury related civilian deaths in the U.S. The Defense and Veterans Brain Injury Center DVBIC has reported over 34,000 moderate to severe combat-related TBI CRTBI since 2000, making it a major source of mortality and morbidity for the U.S. military between 2000 and 2016. The significance of such numbers becomes apparent with the militarys increased focus on Prolonged Field Care PFC and prolonged damage control resuscitation pDCR. PFC is field medical care, applied beyond doctrinal planning time-lines by a SOCM Special Operations Combat Medic or higher, in order to decrease patient mortality and morbidity, utilize limited resources, and provide sustained care until the patient arrives at an appropriate level of care. One of the significant management strategies in the treatment of TBI is aimed at preventing secondary brain damage, which mainly manifests itself as brain ischemia and inflammation. Monitoring of intracranial pressure ICP and cerebral autoregulation CAR to optimize cerebral perfusion pressure CPP to a target and maintain cerebral blood flow CBF are the primary methods to prevent secondary injury and are the mainstays of current practice. In a recent study, Juul et al. has concluded that acute neurological deterioration is a powerful predictor of poor outcomes following TBI. The study showed that 29 of patients with acute neurological decline having an unfavorable outcome and the most powerful predictor of such neurological deterioration was the patients measured ICP. Therefore, it is critical to be able to monitor and manage ICP as early as possible following TBI. Current guidelines of the Brain Trauma Foundation recommend the use of invasive ICP monitoring in patients who meet specific criteria, with the aim of achieving significant reduction in mortality in civilian centers.

Subject Categories:

  • Medicine and Medical Research

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[A, Approved For Public Release]