Preclinical Evaluation of the Effects of Aeromedical Evacuation on Military-Relevant Casualties
[Technical Report, Annual Report]
NAVAL MEDICAL RESEARCH CENTER
Pagination or Media Count:
Aeromedical evacuation is associated with several stressors that may cause harm during casualties transport. In addition to these stressors, timing, oxygen supplementation and altitude may have additional effects that are currently unknown. The purposes of this proposal are to better evaluate the effect of these additional variables and define an adequate timing, oxygen supplementation level and best appropriate altitude to maintain normal organ physiology. This proposal includes the use of two different animal models, rats and swine, using different and complement strategies to better understand the effects of aeromedical evacuation. So far, our results showed the feasibility of our models to monitor the effects of aeromedical evacuation on neurobehavioral damage, inflammatory response and hemodynamic changes. Specifically, we showed no changes in behavioral or pathological changes in the short term of transport after injury in the rat model but noticed modification in the inflammatory response. In addition, we established a swine model that can be used to monitor hemodynamic changes during aeromedical evacuation with different levels of oxygen and altitude.
- Escape, Rescue and Survival
- Medicine and Medical Research
- Weapons Effects (Biological)