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Airborne Pollutants as Triggers of Parkinson's Disease via the Olfactory System

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[Technical Report, Annual Report]

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Michigan State University

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In this multidisciplinary project, we proposed to examine the central hypothesis that ambient air pollutants contribute to Parkinsons disease PD development by initiating andor exacerbating alpha-synuclein pathology at olfactory structures via inflammation. In the epidemiologic arm, we plan to investigate 1 the effect of long-term exposure to air pollutants on olfactory impairment OI 2 whether early PD pathogenesis is exacerbated by ambient air pollutants and 3whether lifetime use of ibuprofen modifies potential adverse effects of air pollutants on OI. The project will leverage ten years of extensive data collection on environmental exposures, medical history, and biospecimen from the well-established Sister Study of the National Institute of Environmental Health Sciences NIEHS. Importantly, we proposed to objectively evaluate the sense of smell of approximately 3,400 Sister Study participants, using the brief smell identification test, efficiently administered by mail. We completed field data collection in March 2019. Of the 4,020 eligible participants, 3,535 87.9 have provided some data, and 3,431 85.3 returned the smell test kit. To date, we have received non-genetic data from our field team at NIEHSSSS. The genotyping was completed in early 2020 at our collaborators lab at the NIA, and a polygenic risk score for PD was created over the summer. We are currently analyzing the nongenetic data to examine the prevalence and correlated factors of OI in our study population, and the relationships between air pollutants of PM2.5 and NO2 and OI.

Subject Categories:

  • Medicine and Medical Research

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[A, Approved For Public Release]