Accession Number:



The Pathogenesis of Post-Traumatic Pulmonary Embolism: A Prospective Multi-center Investigation by the CLOTT Study Group

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

National Trauma Institute d/b/a Coalition for National Trauma Research

Personal Author(s):

Report Date:


Pagination or Media Count:



Venous thromboembolism, which includes both deep vein thrombosis DVT and pulmonary embolism PE, is a common and potentially mortal complication after injury in both civilian and military settings. To date, there are no methods that have been definitively demonstrated to prevent post-traumatic pulmonary embolism PE which carries a mortality of 11 and is the third leading cause of death following injury. PE is particularly common among combat casualties due to the prevalence of certain risk factors such as multiple amputations, traumatic brain injury, the need for transfusions, and prolonged immobilization during evacuation. In Year 3, all sites were enrolling participants except when restricted due to COVID-19 as reported to HRPO. Due to COVID-19, CLOTT Part 2 sites require additional time to meet enrollment targets. A 12-month extension without funds was requested and approved. Four CLOTT Part 2 sites will complete recruitment in Year 4. CLOTT Part 1 sites closed recruitment September 29, 2020. In Year 4, all CLOTT sites 17 will close protocols with the IRB and HRPO, complete data collection, cleaning and analyses. There are no significant findings to report at this time.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]