Accession Number:

AD1122436

Title:

Examination of Neuroimaging, Cognitive Functioning, and Plasma Biomarkers in a Longitudinal Cohort: Fort Devens

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

BOSTON VA RESEARCH INST MA

Personal Author(s):

• Krengel, Maxine

Report Date:

2020-10-01

Pagination or Media Count:

11

Abstract:

This study aims to conduct follow-up longitudinal cognitive evaluations on a sub-sample of 100 Time 3 Ft. Devens Cohort veterans, most of whom were last evaluated in-person for cognitive functioning and with neuroimaging in the mid-1990s, to compare objective measurement of reported decline and to determine cross-sectional blood and neuroimaging biomarkers blood and structural volumetrics will also include longitudinal analyses at 25 years post deployment to the Gulf region, that may be consistent with cognitive outcomes and presumed pathobiological mechanisms oxidative stress, ROS of GWI. These data will evaluate the utility of previously unavailable blood and neuroimaging markers of oxidative stress, to devise a new diagnostic test for GWI in subgroups of GW veterans TBI and OP exposed, and to provide a potential objective biomarker of treatment efficacy in clinical trials.

Descriptors:

• health services
• brain injuries
• data analysis
• institutional review board
• stress (physiology)
• neuroimaging
• persian gulf syndrome
• biomedical research
• central nervous system
• public health
• environmental exposure
• health
• health care
• nervous system
• therapy
• acquisition
• brain
• department of defense
• diseases and disorders
• experimental design

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]