Accession Number:
AD1120942
Title:
Connectome Biomarkers for Predicting Alzheimer's Risk in Traumatic Brain Injury
Descriptive Note:
[Technical Report, Annual Report]
Corporate Author:
Medical University of South CarolinaRalph H. Johnson VA Medical CenterClemson University
Personal Author(s):
Report Date:
2020-10-01
Pagination or Media Count:
12
Abstract:
Many Veterans have suffered a traumatic brain injury TBI, and recent studies have shown that head injury is a risk factor for the development of dementia or Alzheimers Disease AD. Although there is strong emerging evidence that TBI and AD show similarities in neuropathology, measuring cellular and molecular changes following TBI is difficult in clinical populations. However, network analysis of resting state fMRI data is a non-invasive approach that can be used to characterize alterations in network communication in the brain in AD. The overall goal of this project is to characterize brain network alterations in AD as potential biomarkers, then determine whether these biomarkers are already present in the TBI brain, even prior to the onset of cognitive impairment or AD.
Descriptors:
- brain injuries
- alzheimer disease
- medical personnel
- diseases and disorders
- department of defense
- covid-19
- data processing
- risk factors
- abstracts
- biological markers
- data analysis
- cognitive impairment
- positron emission tomography
- positron emissions
- south carolina
- biomedical research
- graph theory
- machine learning
- networks
- patent applications
Subject Categories:
- Psychology
- Medicine and Medical Research
- Weapons Effects (Biological)