Accession Number:



Connectome Biomarkers for Predicting Alzheimer's Risk in Traumatic Brain Injury

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

Medical University of South CarolinaRalph H. Johnson VA Medical CenterClemson University

Personal Author(s):

Report Date:


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Many Veterans have suffered a traumatic brain injury TBI, and recent studies have shown that head injury is a risk factor for the development of dementia or Alzheimers Disease AD. Although there is strong emerging evidence that TBI and AD show similarities in neuropathology, measuring cellular and molecular changes following TBI is difficult in clinical populations. However, network analysis of resting state fMRI data is a non-invasive approach that can be used to characterize alterations in network communication in the brain in AD. The overall goal of this project is to characterize brain network alterations in AD as potential biomarkers, then determine whether these biomarkers are already present in the TBI brain, even prior to the onset of cognitive impairment or AD.

Subject Categories:

  • Psychology
  • Medicine and Medical Research
  • Weapons Effects (Biological)

Distribution Statement:

[A, Approved For Public Release]