Accession Number:



A Novel Visually Graded CT Biomarker of Preinjury Brain Structure to Improve Prediction of Cognitive Decline After Mild Traumatic Brain Injury

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

Northern California Institute for Research and Education

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Mild traumatic brain injury mTBI is a signature injury of modern warfare and affects an estimated 42 million people worldwide each year. MTBI may lead to chronic cognitive problems in memory and thinking ability in up to half of patients. Even more concerning is that mTBI may lead to progressive cognitive decline and eventual Alzheimers dementia AD and AD related disorders ADRD,increasing risk by up to 3-fold. There are currently no practical tools to accurately predict who will suffer from chronic or progressive cognitive consequences of mTBI and who will recover uneventfully. Our project will directly address the overarching challenge of the need for biomarkers and tools to prognose cognitive decline and subsequent progression to ADADRD after mTBI.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]