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A Novel Advanced Resuscitation Fluid for Traumatic Brain Injury with Hemorrhagic Shock

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[Technical Report, Annual Report]

Corporate Author:

University of New Mexico Health SciencesMcGowan Institute for Regenerative Medicine

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Traumatic brain injury TBI is frequently accompanied by hemorrhagic shock HS which significantly worsens neurologic outcome, and increases mortality. Current resuscitation fluids RF for volume expansion after TBI with HS do not adequately ameliorate impaired microvascular cerebral blood flow mvCBF. We suggested the addition of drag reducing polymers DRP to resuscitation fluid DR-RF for TBI with HS which will reduce the severity of brain injury, increase survival rate, improve neurologic recovery and will reduce the volume of resuscitation fluid required to prevent the transition to an irreversible stage and death or functional impairment of the brain. The purpose for the proposed research is to apply DRP as an additive to resuscitation fluids after TBI with HS, to determine which mechanisms are affected by DRP in the acute and late recovery phases and to define most effective parameters for application. During reported period we showed that colloid, hypertonic and colloid-based DRP-RF significantly improves cerebral regional and microvascular circulation and tissue oxygenation impaired by TBIHS. Effect lasts at least 6 hours. Colloid-based DRP-RF was more effective than crystalloid and hypertonicbased DRP-RFtested. We have also done evaluation of TBIHS-induced metabolic stress of mitochondria, hypoxia, neuronal survival and microthrombosis and beneficial effects of DRP-RF-vs. RF. Sub-Contractor performed experiments on DRP characterization and storage and drag reduction test circuit development. The results were presented on 4 conferences, one manuscript published, one accepted and two are in preparation.

Subject Categories:

  • Anatomy and Physiology
  • Biochemistry

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[A, Approved For Public Release]