Accession Number:

AD1116872

Title:

Systems Biology of the Immune Response to Live and Inactivated Dengue Virus Vaccines

Descriptive Note:

Technical Report,01 Sep 2016,01 May 2020

Corporate Author:

University of Rhode Island Kingston United States

Personal Author(s):

Report Date:

2020-09-01

Pagination or Media Count:

15.0

Abstract:

The objective of this project was to elucidate the immunological mechanisms induced by live-attenuated and purified inactivated dengue virus vaccines administered in a heterologous prime-boost regimen. Innate and adaptive T and B cell responses were measured using molecular and cellular approaches, including RNA sequencing, flow cytometry, and multiplex immunoassays. Overall, this project generated a detailed characterization of immune activation and antigen-specific immune responses in subjects from the clinical trial. Analysis of the data has identified candidate early markers of vaccine immunogenicity which are available to be used in future studies of this vaccine, other dengue vaccines, and vaccines against other viral infections.

Subject Categories:

  • Medicine and Medical Research
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE