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Harnessing Neuroplasticity to Enhance Functional Recovery in Allogeneic Hand Transplant and Heterotopic Hand Replant Recipients

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[Technical Report, Annual Report]

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The overarching hypothesis of this project is that patients recovering from hand transplants, replants and peripheral nerve repairs will exhibit improved hand function resulting from combined transcranial direct current stimulation and behavioral therapies that seek to reverse persistent, amputation-related brain reorganization. This work builds on solid basic findings in neuroscience to develop, implement and evaluate innovative evidence-based rehabilitation in hand transplant, replant and peripheral nerve repair patients. This project will yield effective new therapeutic approaches for improving outcomes of individuals who have undergone hand transplantation, replantation, and peripheral nerve repairs that can be deployed with modest training and minimal cost in a wide variety of settings, including the theatre of engagement. The therapeutic approaches resulting from this work will lead to improved hand function in wounded warriors and civilians, providing them with an improved quality of life through the resumption of meaningful pre-morbid occupational, recreational, familial and social activities.

Subject Categories:

  • Medicine and Medical Research

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[A, Approved For Public Release]