The Prenatal Origins of Autism Spectrum Disorder
[Technical Report, Annual Report]
Henry Ford Health System
Pagination or Media Count:
This study seeks to examine the interrelationships of placental histopathology, placental and neonatal angiogenesis, and ASD severity. In doing so, it addresses two critical gaps in ASD knowledge 1 why the majority of ASD cases are male and 2 mechanisms underlying the heterogeneity of ASD symptoms. In addition, it will open the door to non-invasive placenta-based diagnosis at the time of birth, well before onset of red-flag symptoms. This study is leveraging existing data, resources, and biologic samples as well as physician partnerships to conduct a study of 177 ASD cases 62 with archived placental tissue and 62 frequency matched controls born in Michigan between 2012 and 2017. ASD cases are extensively evaluated by a team of experts at the Henry Ford Health System Center for Autism and Developmental Disabilities and have detailed diagnostic information including severity level in their electronic medical record. Neonatal angiogenic profile will be measured in archived dried blood spots from Michigans Newborn Screening Program. Placental histopathology and angiogenic markers will be assessed in archived placental tissue from 62 cases and 62 typically developing controls frequency matched on year of birth, preterm status, and sex.
- Anatomy and Physiology
- Medicine and Medical Research