Instrumentation Platform for Imaging Cell Membrane Dynamics
Technical Report,15 Jun 2018,14 Jun 2020
TRUSTEES OF BOSTON UNIVERSITY BOSTON United States
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In this DURIP grant, the acquisition of equipment for microscopy from visible to infrared wavelengths in one imaging platform was proposed, thus combining fluorescence imaging with infrared vibrational spectroscopy. This allows detection of fluorescently labeled probes in biological specimens, identification of label-free bond-specific inherent spectral signatures, characterization of phase transitions and of the underlying structural order of molecules. The development of such a technology platform aims to advance the scientific development and technology progress for external nerve stimulation and inhibition. Specifically, novel insights into the biophysical mechanisms during infrared nerve stimulation and other external neuromodulation schemes will be gained by resolving the structure and dynamics of the cell membrane during different neuro-stimulation challenges and to analyze cell membrane dynamics.