Accession Number:

AD1112058

Title:

Targeting the Endotheliopathy of Trauma in Hemorrhagic Shock and Traumatic Brain Injury with Freeze-Dried Platelets

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

Personal Author(s):

• Pati, Shibani
• Mahuvakar, Alpa

Report Date:

2020-09-01

Pagination or Media Count:

22

Abstract:

The goal of this project is to test the therapeutic potential of freeze dried platelets-FDPlts Thrombosomes- in disease conditions characterized by 1 inflammation, 2 vascular instability and 3 coagulation disturbances, which are all components of the endotheliopathy of trauma EOT refs. Aside from their hemostatic properties, this proposal aims to also determine the mechanisms of action of the freeze dried platelets FDPlts Thrombosomes on the EOT in traumatic brain injury TBI and shock induced acute lung injury ALI all conditions with few if any effective treatment options. We hypothesize that FDPlts Thrombosomes will have potent hemostatic properties comparable to fresh platelets and that they will attenuate and mitigate the endotheliopathy of trauma EOT in TBI and HS induced ALI. We hypothesize that FDPlts Thrombosomes can be used as a stand-alone early therapy to mitigate outcomes in trauma.

Descriptors:

• medical personnel
• data analysis
• brain injuries
• hemorrhagic shock
• wounds and injuries
• therapy
• intercellular junctions
• arteries
• blood
• cardiovascular physiological phenomena
• cells
• diseases and disorders
• epithelial cells
• body weight
• fetus
• statistical analysis
• students
• tissues
• biomedical research
• catheters

Subject Categories:

• Medicine and Medical Research
• Biology

Distribution Statement:

[A, Approved For Public Release]