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Targeted Nanobubble Technology to Control Diabetic Macrophage Function

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[Technical Report, Annual Report]

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Purpose and Scope. The use of micro- and nanobubble systems combined with ultrasound US for drug and gene delivery hasgained attention because the US can be used to trigger and enhance delivery via sonoporation. The objective of the proposedresearch is to develop a novel approach of miR-21 mimic cargo delivery using targeted gas nonobubbles. The delivery isanticipated to improve plasticity of injury-site macrophages in diabetic ulcers thus, facilitating resolution of inflammation andpromote wound healing. Results and Significance. I Successfully formulated macrophage targeted cationic nanobubbles mNBwhich are sufficiently stable to allow for adequate therapy time. II optimized the delivery of mNB in excisional wounds that wastrackable under US imaging using Vevo2100. In preliminary experiments, the delivery resulted in improved wound closure in adelayed wound healing mice model of miR-21lysM cre.

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  • Medicine and Medical Research

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[A, Approved For Public Release]