Accession Number:

AD1112026

Title:

Comparison of Transcutaneous and End-Tidal CO2 Measurements in Aerospace Environments

Descriptive Note:

[Technical Report, Technical Report]

Corporate Author:

NAVAL MEDICAL RESEARCH UNIT (DAYTON) WRIGHT-PATTERSON AFB OHOAK RIDGE INST FOR SCIENCE AND EDUCATION WRIGHT-PATTERSON AFB OHICON GPHS

Personal Author(s):

• Shykoff, Barbara E.
• Lee, Lesley A.
• Warkander, Dan E.
• Robinson, F. E.
• Gallo, Megan A.
• Griswold, Cheryl

Report Date:

2020-10-01

Pagination or Media Count:

33

Abstract:

Transcutaneous monitoring of carbon dioxide CO2 has been proposed for use in physiological monitoring of tactical jet aircrew because in some clinical settings it provides useful information about control of arterial CO2 partial pressure. End tidal monitoring in a laboratory setting is known to give high-fidelity estimates of arterial CO2 partial pressure PCO2. The correspondence between end-tidal PETCO2 and transcutaneous tcPCO2 measures of PCO2 was examined under conditions of hyperoxia and hypoxia in healthy volunteers in a laboratory. Rest and exercise, skin heating and cooling, hyperventilation, and induced CO2 retention were employed. Resting measurements at or near normoxia, and exercise measurements during breathing of 40 O2 were also examined. Bland-Altman analysis of tcPCO2 and PETCO2 showed that the two were equivalent only during normoxic resting measurements. Regression analysis indicated that tissue PO2 measured as transcutaneous PO2 tcPO2 is an important explanatory variable for tcPCO2 in addition to PETCO2, and that local skin temperature also has an effect. Additionally, prolonged sitting while breathing 100 O2 and hypoxic exercise caused PETCO2 to deviate from PaCO2. Thus, tcPCO2 is not useful as even a trend indicator for arterial PCO2 in the highly dynamic tactical jet aircraft environment. PETCO2 is also not a good indicator of CO2 status in pilots who breathe nearly 100 O2.

Descriptors:

• health services
• respiratory physiological phenomena
• measurement
• regression analysis
• barometric pressure
• blood
• oxygenation
• respiration disorders
• institutional review board
• sea level
• aerospace environments
• biomedical research
• ground level
• heart rate
• information science
• partial pressure
• carbon dioxide
• cooling
• data science
• data sets

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology
• Inorganic Chemistry

Distribution Statement:

[A, Approved For Public Release]