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Transform Off-the-Shelf Synthetic Grafts to Autologous Conduits for Coronary Artery Bypass Grafting

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[Technical Report, Annual Report]

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INTRODUCTION Coronary arterial disease is the leading cause of death in the United States in both women and men. Arterial disease of theheart alone costs well over 2.5B for the VA system alone. To meet this challenge, we design vascular grafts made of special rubbers that aredesigned and patented specifically for vascular grafting. Unlike current grafts on the market or in clinical trials, the patients own body willchange these grafts over time to their own vessels. The two aims of this project are 1. Finalize graft fabrication methodology and select thebest design using a rat carotid artery model. And 2. Evaluate the performance of the selected grafts in a pig coronary artery bypass graftingmodel.


Subject Categories:

  • Medicine and Medical Research
  • Medical Facilities, Equipment and Supplies
  • Elastomers and Rubber

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[A, Approved For Public Release]