Accession Number:

AD1111627

Title:

Preclinical Validation of (+)-Epicatechin for the Treatment of Gulf War Illness

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

University of California

Personal Author(s):

Report Date:

2020-09-01

Pagination or Media Count:

24

Abstract:

In this project we propose to, Validate using an animal model of Gulf War illness GWI, the capacity of -epicatechin Epi to reverse neurological and skeletal muscle SkM mitochondrial dysfunction, oxidative stress OS and loss of organ function. Aim 1 is to characterize using an animal model of GWI, changes in hippocampus and SkM function, mitochondria structurefunction and OS related endpoints. A rat model of GWI will be used to characterize short and long-term changes in hippocampus and SkM mitochondria, OS including redox control and organ function. Animals will be exposed to the chemicals for 1 month and changes evaluated in hippocampus and SkM function sequentially for up to 1 year. Control animals will only be exposed to vehicles. Collected tissues will be used to assess for changes in structural, biochemical and functional mitochondrial and OS related endpoints. Aim 2 is to examine the capacity of -Epi to reverse GWI related changes in hippocampus and SkM OS, mitochondria structurefunction and organ function. Using the rat model of GWI and time points relevant for evaluation we will examine the capacity of -Epi provided orally from 4 weeks to several months to mitigate OS, improve hippocampus and SkM mitochondria structurefunction and organ function. As above, tissues will be collected to ascertain for changes in structural, biochemical and functional endpoints.

Descriptors:

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]