Pulsed Electromagnetic Field Therapy for Accelerating Peripheral Nerve Regeneration and Preserving Neuromuscular Junctions
[Technical Report, Annual Report]
WAKE FOREST UNIVERSITY HEALTH SCIENCES
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Major accomplishments include receipt of IACUC and ACURO approvals for all animal protocols, receipt and installation of a PEMF cage system providing commercially available PEMF waveforms, and initiation of experiments in Specific Aims 1 and 2. The PEMF cage system is installed in a dedicated room in the Wake Forest vivarium. Caging does not interfere with the PEMF waveform. Rats were placed on study to address Specific Aims 1, 2, 3. Initial gait analysis was performed, the sciatic nerve was transected and repaired, and the animals received PEMF treatment for 4, 3, or 2 months. Animals underwent functional testing utilizing EMG and muscle force generation following their last gait analysis. Specific Aim 3 ability of PEMF to sustain neuromuscular junctions was initiated Animals were place on study following nerve transection without repair in December 2018. They were treated for 4 months. A second cohort was placed on study for a treatment period of 3 months.
- Anatomy and Physiology