Preventing Ototoxic Synergy of Prior Noise Trauma during Aminoglycoside Therapy
[Technical Report, Annual Report]
VA Loma Linda Healthcare System
Pagination or Media Count:
We successfully identified two molecular targets among a handful candidates that may contribute to an escalated inner ear ototoxicity. One is the Duffy antigen receptor for chemokines Darc, and the other is the transient receptor potential vanilloid 1 TrpV1. Both receptors actively participate in the process of cochlear inflammation, a condition resulting from exposure to moderate and intense noise stimulation. During this reporting period, we continued research activities using electrophysiology, immunohistochemistry, and cochlear perfusion techniques to conduct proposed experiments. The effect of inflammation on drug- or noise-induced ototoxicity was further investigated, using the application of LPS or aminoglycosides. Acquired data were analyzed thoroughly and reported at conferences and prepared in manuscripts for peer-reviewed publication.
- Medicine and Medical Research