Accession Number:

AD1110995

Title:

Nebulized in-Line Endotracheal Dornase Alfa and Albuterol Administered to Mechanically Ventilated COVID-19 Patients: A Case Series

Descriptive Note:

Journal Article - Open Access

Corporate Author:

NORTH SHORE HOSPITAL MANHASSET NY MANHASSET United States

Report Date:

2020-09-29

Pagination or Media Count:

7.0

Abstract:

Mechanically ventilated patients with COVID-19 have a mortality of 2453, in part due to distal mucopurulent secretions interfering with ventilation. DNA from neutrophil extracellular traps NETs contribute to the viscosity of mucopurulent secretions and NETs are found in the serum of COVID-19 patients. Dornase alfa is recombinant human DNase 1 and is used to digest DNA in mucoid sputum. Here, we report a single-center case series where dornase alfa was co-administered with albuterol through an in-line nebulizer system.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE