Nebulized in-Line Endotracheal Dornase Alfa and Albuterol Administered to Mechanically Ventilated COVID-19 Patients: A Case Series
Journal Article - Open Access
NORTH SHORE HOSPITAL MANHASSET NY MANHASSET United States
Pagination or Media Count:
Mechanically ventilated patients with COVID-19 have a mortality of 2453, in part due to distal mucopurulent secretions interfering with ventilation. DNA from neutrophil extracellular traps NETs contribute to the viscosity of mucopurulent secretions and NETs are found in the serum of COVID-19 patients. Dornase alfa is recombinant human DNase 1 and is used to digest DNA in mucoid sputum. Here, we report a single-center case series where dornase alfa was co-administered with albuterol through an in-line nebulizer system.
- Anatomy and Physiology
- Medicine and Medical Research