Toward a Molecular Understanding of Noise-Induced Hearing Loss
Technical Report,30 Sep 2014,29 Sep 2019
University of Maryland School of Medicine Baltimore United States
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The purpose of this project is to generate the cell type-specific molecular blueprint of changes in gene expression following different types of noise exposure and their treatments, in the inner ear. To this end, we have a Established the hair cell HC and supporting SC cell-specific translatomes of adult mouse inner ears and identified key regulators of OHC maturation and function b Established the molecular changes induced by permanent and temporary threshold shift resulting noise exposure in HC, SC and whole inner ears, 6 and 24 hours after noise exposure c We identified critical differences in the response of male and female mice to noise, and obtained approval to modify Specific Aim 3 to repeat the baseline as well as temporary and permanent threshold shift analysis using male and female mice separately.
- Medicine and Medical Research
- Anatomy and Physiology
- Genetic Engineering and Molecular Biology