TCR-Engineered T Cell Immunotherapy for Epithelial Ovarian Cancer Enhanced by TGFbeta Blockade and Epigenetic Modulation
Technical Report,15 Jul 2018,14 Jul 2019
Roswell Park Comprehensive Cancer Center BUFFALO United States
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This is a project to test the hypothesis that the combination of epigenetic modification Decitabine and adoptive cell therapy ACT of NY- ESO-1 TCR dnTGFBetaRII engineered T cells will be safe and show improved clinical responses in women who have recurrentpersistent platinum-resistant ovarian cancers. We had successfully reached the milestones for the first year We injected the highest dose of T cell 10e9 transgenic T cells in the last cohort of our Phase I clinical trial with NY-ESO-1 TCRdnTGFBetaRII engineered T cells for solid- tumors including Ovarian Ca. FDA approval IND 17410, clinicaltrials.gov reg. NCT02650986. And we successfully got approval from IRB and FDA to add Decitabine to the clinical trial as proposed.
- Medicine and Medical Research