Accession Number:

AD1105505

Title:

Mechanisms Underlying Stress Fracture and the Influence of Sex and Race/Ethnicity

Descriptive Note:

Technical Report,30 Sep 2018,29 Sep 2019

Corporate Author:

Massachusetts General Hospital Boston United States

Personal Author(s):

• Bouxsein,Mary
• Popp,Kristin
• Loranger,Elizabeth
• Gehman,Sarah

Report Date:

2019-10-01

Pagination or Media Count:

17.0

Abstract:

This cross-sectional clinical study aims to examine potential mechanisms contributing to stress fracture risk. In Aim 1 we will perform advanced skeletal imaging along with gait-assessments in subjects with history of a single vs multiple vs no prior stress fractures. In Aim 2 we will perform advanced skeletal imaging to delineate variation in skeletal features according to sex and raceethnic-origin that may contribute to or protect from stress fracture. To date, we have achieved the enrollment goal for Study 1 of 45 subjects, 42 of whom have completed all study visits. Data collection and cleaning are ongoing, and preliminary analysis has been performed for biomechanical and bone microarchitecture data. For Aim 2, 146 subjects 81 of targeted enrollment have been enrolled and have completed testing. Data collection and cleaning are ongoing.

Descriptors:

• ethnic groups
• biomedical research
• bone fractures
• sex
• data analysis

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE