The Relationship Between Brain Functioning, Behavior, and Microbiota in Autism Spectrum Disorder
Technical Report,01 Sep 2018,31 Aug 2019
University of California Los Angeles Los Angeles United States
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While social communication deficits are considered the hallmark of autism spectrum disorder ASD, comorbid gastrointestinal GI issues are common and impair quality of life in a large subset of affected individuals. Several studies have linked these GI issues to altered gut microbial composition, or dysbiosis, in ASD. Yet research has not yet clarified how dysbiosis may be related to the core features of ASD or to the symptom heterogeneity of this disorder. A growing number of studies support the concept that gut microbiota can signal to the brain by neural, endocrine, immune, and hormonal pathways. These microbial effects on the brain may modulate outputs in behavior, as well as in autonomic and neuroendocrine function.
- Anatomy and Physiology