Accession Number:

AD1105432

Title:

Evaluation of Lipid Poor Renal Masses with Magnetic Resonance Spectroscopy in Tuberous Sclerosis Complex

Descriptive Note:

Technical Report,01 Sep 2018,31 Aug 2019

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON BOSTON

Personal Author(s):

Report Date:

2019-09-01

Pagination or Media Count:

55.0

Abstract:

The Research Project supported by this DOD Award investigates the potential of in vivo and ex vivo MRS in characterizing the metabolomic spectra of TSC-associated renal masses. In an effort to optimize our in vivo image acquisition protocol, we began by scanning healthy volunteers and have formalized our novel in vivo MRS protocol, which will be submitted for publication. Subsequently, our overall enrollment of TSC patients with lipid poor renal masses has been lower than expected. For this reason and in order to meet our goals of gaining more metabolomic data on renal masses, we have expanded our subjects to include TSC patients with lipid rich masses, non-TSC patients with lipid poor and lipid rich renal masses. We continue to enroll patients and analyze our current and ongoing data. Our analysis cohort also will be expanded with the utilization of our genitourinary oncology tumor bank, including AML and other renal tumor tissue. The findings from this study will help the TSC community gain an understanding of the metabolomics of AML and other renal tumors.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE