89Zr-Trastuzumab-PET, Rapid Autopsies, and Patient Derived Xenografts to Determine the Extent of Clonal Evolution in Treatment Refractory HER2+ Gastric Cancer
Technical Report,01 Sep 2016,31 Aug 2019
SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK NEW YORK United States
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Trastuzumab, an FDA approved monoclonal antibody that binds to the extracellular domain of HER2, is the standard of care for these patients. However, after an initial response secondary resistance invariably ensues. The molecular basis of therapeutic resistance in HER2-positive EG cancer remains unknown and, until now, no other HER2-directed therapy has shown clinical efficacy in patients with trastuzumab refractory EG cancer.
- Medicine and Medical Research