Placenta-on-a-Chip: In Vitro Study of Caffeine Transport across Placental Barrier Using Liquid Chromatography Mass Spectrometry
Journal Article - Open Access
Iowa State University Ames United States
Pagination or Media Count:
Due to the particular structure and functionality of the placenta, most current human placenta drug testing methods are limited to animal models, conventional cell testing, and cohortcontrolled testing. Previous studies have produced inconsistent results due to physiological differences between humans and animals and limited availability of human andor animal models for controlled testing. To overcome these challenges, a placenta-on-a-chip system is developed for studying the exchange of substances to and from the placenta. Caffeine transport across the placental barrier is studied because caffeine is a xenobiotic widely consumed on a daily basis.
- Anatomy and Physiology
- Atomic and Molecular Physics and Spectroscopy