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Changes in Circulating Levels of the Traumatic Brain Injury Biomarkers S100B and UCH-L1 in Soman Exposed Sprague Dawley Rats

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Technical Report

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Battelle Memorial Institute Columbus United States

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Organophosphorus OP chemical warfare nerve agents CWNAs and pesticides exert toxicity primarily through the inhibition of acetylcholinesterase. If left uncontrolled, hypersynchronous activity within the central nervous system can result in neuronal loss, neuroinflammation, and network reorganization. While these pathological outcomes are common to many neurodegenerative conditions, it remains unresolved whether OP-induced toxicity also results in detectable changes in circulating protein levels similar to other CNS injuries. The goal of this pilot study was to identify circulating proteins that may serve as indicators of OP-induced toxicity. Adult male Sprague-Dawley rats were challenged with the CWNA soman and monitored over 72h post-exposure. Blood was collected at 6h, 24h, and 72h post-exposure and analyzed for candidate biomarker levels. The circulating protein candidates selected were based on other central injury models and included BDNF, GFAP, NSE, NMDAR, S100B, and UCH-L1. Significant changes were observed in the serum levels of S100B and UCH-L1. Collectively, this study demonstrates that in addition to quantifying cholinesterase activity, circulating proteins could be utilized to corroborate OP exposure. Additional studies are warranted to identify whether changes in the levels of these circulating proteins may also correlate with the extent of neuronal injury following OP exposure to guide therapeutic treatment.

Subject Categories:

  • Chemical, Biological and Radiological Warfare
  • Medicine and Medical Research

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