Commensal Bacteria with High Homology to Nonmutated Tumor Antigens May Prevent Clinically Effective Vaccination in Breast Cancer
Technical Report,15 Mar 2019,14 Mar 2020
University of Washington Seattle United States
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We previously found a significant association of numerous sequence homologies to bacterial species found in the gut microbiome with IL-10-inducing Class II epitopes to tumor antigens and hypothesized that those microbialtumor antigen-specific T-cells will prevent an anti-tumor immune response from developing. Aim 1 is 90 percent complete. We have demonstrated here that T-cells specific for Pseudomonas aeruginosa and the less than 50 percent homologous tumor antigen, YB1, can traffic to an TgMMTV-neu tumor implant. The bacterial and tumor antigen cross-reactive T-cells subsequently promoted tumor growth. These results speak to a potential mechanism as to why whole protein vaccines have been unsuccessful in demonstrating anti-tumor activity in Phase III clinical trials.
- Medicine and Medical Research