Omega-3 Polyunsaturated Fatty Acid Status, Microglial Activation, Stress Resilience, and Cognitive Performance
Technical Report,01 May 2019,30 Apr 2020
Oregon Health and Science University Portland United States
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It is widely reported across mammalian species that deficiency in the dietary intake of omega-3 polyunsaturated fatty acids n-3 PUFA negatively impacts cognitive performance and mood. A plethora of literature also implicates n-3 PUFA deficiency in disorders such as ADHD, PTSD, major depressive and bipolar disorders, and schizophrenia. Defining potential neuronal mechanisms that link n-3 PUFA levels to cognitive and behavioral deficits has important implications given that the trend of the modern diet has been toward reduced n-3 PUFA intake. Here, we propose human and rodent experiments to evaluate whether the anti-inflammationpro-resolution effects of n-3 PUFA deficiency contribute to the adverse effects on cognitive performance and affect. In addition, these experiments focus on the expression of dietary n-3 PUFA deficiency in late adolescenceyoung adulthooda developmentally critical period during which an individual is vulnerable to mood, psychotic and addictive disorders. We will use a positron emission tomography PET imaging strategy in humans as a marker of activated microglia in individuals with low and high plasma n-3 PUFA. In parallel animal studies, we will directly measure microglia activation in an animal model of n-3 PUFA deficiency and determine whether supplementation during early adulthood reverses this effect in correlation with behavior.