Toxicity Study No. S.005223.2 19, March 2020 Protocol No. OFMA 92 iv17.03 01S, 2758 70 iv19 04 01F and 49iv19 03 01ETiered In Vitro Toxicity Testing of the Novel Energetic 1 methyl 2,4.5 trinitroimidazole (MTNI)
Technical Report,01 Apr 2019,30 Sep 2019
U.S. Army Public Health Center Aberden Proving Ground United States
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The Army is identifying replacements for substances causing environmental andor occupational risks. IMTNI was evaluated in several in vitro test systems, including the Ames mutagenicity assay, the Microtox Acute Toxicity Test System, and the human cell line activation test h-CLAT for skin sensitization. Data from the h-CLAT were also utilized to predict a Hazard Category for acute oral toxicity. MTNI was found to be extremely toxic in all assays completed, mutagenic in the Ames, and a sensitizer in h-CLAT. The high aquatic toxicity combined with high solubility of MTNI causes concern for environmental and groundwater contamination. Additional aquatic testing should be conducted. Skin contact with MTNI should be avoided.