Repeat Anaphylaxis to the MMR Vaccine Mediated by IgE Sensitivity to Gelatin
59MDW San Antonio United States
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It is estimated that a severe allergic reaction to any vaccine occurs at a rate of 1 per 1.3 per million doses of vaccines given. MMR is typically a well tolerated vaccination with rare reports of severe allergic reactions. Reactions to the MMR vaccine are often caused by additive or residual vaccine components. In addition to MMR viral antigens, the vaccine also contains egg protein, neomycin, sorbitol, and gelatin. MMR vaccination is mandatory for new recruits in the military. We report a case of anaphylaxis following MMR vaccination. Laboratory and skin testing suggest that anaphylaxis was due to an IgE mediated antibody reaction to the gelatin component of the vaccine.
- Medicine and Medical Research