Accession Number:

AD1101265

Title:

Enhancing Immunotherapy with Novel Combinations to Improve the Treatment of Primary and Metastatic Colon Cancer

Descriptive Note:

Technical Report,01 Sep 2019,23 Jan 2020

Corporate Author:

University of Illinois at Chicago Chicago United States

Personal Author(s):

Report Date:

2020-01-01

Pagination or Media Count:

13.0

Abstract:

Our goal is to improve the control of advanced colon cancer by enhancing anti-tumor immune responses by stimulating the immune system to increase the infiltration and activation of anti-tumor lymphocytes in colon cancer tumors. We believe that the tumor microenvironment can be manipulated to enhance cytotoxic lymphocyte infiltration and activation, and that immune-checkpoint blockade with anti-CTLA4 therapy can be simultaneously utilized to augment a clinically relevant immune response. Once it is known how to enhance immunostimulatory signals in the tumor microenvironment and simultaneously suppress immunosuppressive influences, a new strategy for the management of colon cancer with the potential for durable anti-tumor responses and improved survival is possible. In this time period we have prepared data to investigate immunostimulation of colon cancer cells, preparing them for enhanced lymphocyte proliferation and susceptibility to anti-CTLA4 checkpoint blockade.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE