Central Mechanisms and Treatment of Blast-Induced Auditory and Vestibular Injuries
Technical Report,30 Dec 2018,29 Dec 2019
The Geneva Foundation Tacoma United States
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The study is to utilize our well-defined shock tube simulation of mild blast-induced traumatic brain injury bTBI in rodents to characterize interrelated biomechanical and pathophysiological mechanisms of blast-induced central auditory processing disorders CAPDs and central vestibular injuries CVIs and to develop an early therapeutic intervention for hearing loss and balance disorder mitigation. The major objectives of the proposed studies and relevant research sub-gaps are 1 Verify the time course of hearing loss and balance disorders induced by blast exposure and define plasma and CSF TDP-43 as a biomarker related to blast-induced central auditoryvestibular deficits 2 Characterize blast induced biochemical, functional and morphological alterations in central auditoryvestibular systems and establish that blast-induced altered expression of TDP-43 and its BDPs in these structures play a key pathophysiological mechanism leading to secondary injuries.
- Anatomy and Physiology