Synthesis of a Reactive Oxygen Species-Responsive Doxorubicin Derivative
Journal Article - Open Access
NAVAL RESEARCH LAB WASHINGTON DC WASHINGTON United States
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A heterobifunctional reactive oxygen species ROS-responsive linker for directed drug assembly onto and delivery from a quantum dot QD nanoparticle carrier was synthesized and coupled to doxorubicin using N-3-dimethylaminopropyl-N-ethylcarbodiimide hydrochloride EDCsulfo-NHS coupling. The doxorubicin conjugate was characterized using H-1 NMR and LC-MS and subsequently reacted under conditions of ROS formation Cu2 H2O2 resulting in successful and rapid thioacetal oxidative cleavage, which was monitored using H-1 NMR.
- Physical Chemistry