Accession Number:

AD1100669

Title:

Synthesis of a Reactive Oxygen Species-Responsive Doxorubicin Derivative

Descriptive Note:

Journal Article - Open Access

Corporate Author:

NAVAL RESEARCH LAB WASHINGTON DC WASHINGTON United States

Report Date:

2018-07-21

Pagination or Media Count:

5.0

Abstract:

A heterobifunctional reactive oxygen species ROS-responsive linker for directed drug assembly onto and delivery from a quantum dot QD nanoparticle carrier was synthesized and coupled to doxorubicin using N-3-dimethylaminopropyl-N-ethylcarbodiimide hydrochloride EDCsulfo-NHS coupling. The doxorubicin conjugate was characterized using H-1 NMR and LC-MS and subsequently reacted under conditions of ROS formation Cu2 H2O2 resulting in successful and rapid thioacetal oxidative cleavage, which was monitored using H-1 NMR.

Subject Categories:

  • Physical Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE