Synthesis and Kinetics of Disassembly for Silyl-Containing Ethoxycarbonyls Using Fluoride Ions
Journal Article - Open Access
NAVAL RESEARCH LAB WASHINGTON DC WASHINGTON United States
Pagination or Media Count:
In this study, a series of silyl-containing ethoxycarbonates and ethoxycarbamates on electron poor anilines and phenols were synthesized and their kinetics of disassembly determined in real-time upon exposure to fluoride ion sources at room temperature. The results provide a greater understanding of stability and kinetics for silyl-containing protecting groups that eliminate volatile molecules upon removal, which will allow for simplification of orthogonal protection in complex organic molecules.
- Physical Chemistry
- Organic Chemistry
- Inorganic Chemistry