Validating Epigenetic and Genetic Biomarkers for Diagnosis of Bladder Pain of Interstitial Cystitis
Technical Report,01 Apr 2019,31 Mar 2020
Cedars-Sinai Medical Center Los Angeles United States
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The goal of this study is to determine the biosignature consisting of DNA methylation and gene expression status detected in urine from interstitial cystitispainful bladder syndrome IC patients will stratify IC patients from healthy controls. In this funding year, we have focused on 1 identification on baseline of urine collection, 2 expansion of database for better urine biomarker discovery, and 3 technology application to further identify the DNA methylation markers associated with IC. In particular, we were able to optimize the DNA methylation and gene expression assays, which were designed for high throughput screening HTS.
- Anatomy and Physiology
- Medicine and Medical Research