Proinflammatory Epithelial Cells as a Therapeutic Target in Chronic Pancreatitis
Technical Report,01 Jun 2019,31 May 2020
University of Utah Salt Lake City United States
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The focus of our study is the role of de-differentiated exocrine acinar cells in perpetuating inflammation and tissue injury in chronic pancreatitis. We hypothesize that the pro-differentiation transcription factor Ptf1a promotes recovery from acute pancreatitis, in part through secretion of anti-inflammatory signals such as FGF21, and that downregulation of Ptf1a in chronic pancreatitis leads to sustained inflammation. We have made only limited progress, unfortunately, although the personnel issues that affected us in the beginning of the project have been resolved. We have a large series of experimental mouse samples harvested and fixed, ready to analyze as work on campus begins to resume we have moved to a partially-open status this month.
- Medicine and Medical Research