Endogenous and Exogenous Pericytes in the Pathobiology and Treatment of Osteoarthritis
Technical Report,01 Jul 2018,31 Dec 2019
Johns Hopkins University Baltimore United States
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Pdgfrb transgenic reporter animals represent a tool for the visualization of pericytes within joint associated tissues. Destabilization of the medial meniscus in the mouse induces osteoarthritic changes associated with dynamic changes in the vasculature and Pdgfrb reporter activity within the infrapatellar fat pad. These changes implicate endogenous pericytes as a key cellular player in post-traumatic osteoarthritis.
- Medicine and Medical Research