Neurosteroid and Benzodiazepine Combination Therapy Reduces Status Epilepticus and Long-Term Effects of Whole-Body Sarin Exposure in Rats
Journal Article - Open Access
US Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground United States
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Key Points Sarin whole body exposure in rats results in benzodiazepine pharmaco resistant status epilepticus when diazepam treatment is delayed. Performance deficits in the Morris water maze and severe brain pathology are present in the months after whole body exposure to sarin in diazepam-treated rats. Delayed pregnanolone and diazepam dual therapy rapidly terminates status epilepticus in sarin exposed rats compared with diazepam monotherapy. Delayed pregnanolone and diazepam dual therapy provides functional and neuronal protection against sarin exposure. Neurosteroid treatment may be a promising adjunct to benzodiazepines in treating refractory status epilepticus.
- Anatomy and Physiology
- Medicine and Medical Research