Accession Number:

AD1099742

Title:

Soman-Induced Status Epilepticus, Epileptogenesis, and Neuropathology in Carboxylesterase Knockout Mice Treated with Midazolam

Descriptive Note:

Journal Article - Open Access

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD ABERDEEN PROVING GROUND United States

Personal Author(s):

• Marrero-Rosado, Brenda
• de Araujo Furtado,Marcio
• Schultz,Caroline R.
• Stone,Michael
• Kundrick,Erica
• Walker,Katie
• O'Brien,Sean
• Du,Fu
• Lumley,Lucille A.

Report Date:

2018-10-25

Pagination or Media Count:

14.0

Abstract:

Carboxylesterase knockout ES1 mice are more susceptible than wild-type C57BL6 mice to the lethal effects of soman. Spontaneous recurrent seizures develop in ES1 mice following soman-induced status epilepticus when midazolam treatment is delayed. Severe neuronal loss and neuroinflammation are present in ES1 mice 2 weeks following soman-induced status epilepticus. ES1 mice show acute and subchronic electroencephalography EEG power spectra changes after soman-induced status epilepticus and midazolam treatment is delayed.

Descriptors:

• nerve agents
• chemical warfare
• gd agent
• organophosphorus compounds
• seizures
• brain
• cognitive impairment
• laboratory animals
• case studies

Subject Categories:

• Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE