Soman-Induced Status Epilepticus, Epileptogenesis, and Neuropathology in Carboxylesterase Knockout Mice Treated with Midazolam
Journal Article - Open Access
ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD ABERDEEN PROVING GROUND United States
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Carboxylesterase knockout ES1 mice are more susceptible than wild-type C57BL6 mice to the lethal effects of soman. Spontaneous recurrent seizures develop in ES1 mice following soman-induced status epilepticus when midazolam treatment is delayed. Severe neuronal loss and neuroinflammation are present in ES1 mice 2 weeks following soman-induced status epilepticus. ES1 mice show acute and subchronic electroencephalography EEG power spectra changes after soman-induced status epilepticus and midazolam treatment is delayed.
- Chemical, Biological and Radiological Warfare