Human Cell Line Activation Test of the Novel Energetic N,N'- bis(4 nitro 1,2,5 oxadiazol 3 yl)-methanediamine (MBANF)
Technical Report,01 Feb 2020,31 Mar 2020
Army Public Health Center Aberdeen Proving Ground United States
Pagination or Media Count:
The energetic and toxicological properties of n,n-bis4-nitro-1,2,5-oxadiazol-3-yl-methanediamine MBANF are under assessment as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine RD and trinitrotoluene TNT. This study evaluated the skin sensitization hazard of MBANF through the h-CLAT, an in vitro approach to assess activation of dendritic cells. Data from the h-CLAT were also utilized to predict a Hazard Category UNECE2015 for acute oral toxicity. Data from this study are used to assist in making environment and health-based decisions regarding the design and selection of formulas and materials for development of new munition compounds.
- Anatomy and Physiology
- Environmental Health and Safety