Accession Number:

AD1099566

Title:

Human Cell Line Activation Test of the Novel Energetic N,N'- bis(4 nitro 1,2,5 oxadiazol 3 yl)-methanediamine (MBANF)

Descriptive Note:

Technical Report,01 Feb 2020,31 Mar 2020

Corporate Author:

Army Public Health Center Aberdeen Proving Ground United States

Personal Author(s):

• Reinke, Emily N.

Report Date:

2020-03-01

Pagination or Media Count:

40.0

Abstract:

The energetic and toxicological properties of n,n-bis4-nitro-1,2,5-oxadiazol-3-yl-methanediamine MBANF are under assessment as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine RD and trinitrotoluene TNT. This study evaluated the skin sensitization hazard of MBANF through the h-CLAT, an in vitro approach to assess activation of dendritic cells. Data from the h-CLAT were also utilized to predict a Hazard Category UNECE2015 for acute oral toxicity. Data from this study are used to assist in making environment and health-based decisions regarding the design and selection of formulas and materials for development of new munition compounds.

Descriptors:

• cell lines
• toxicity
• toxicology
• rdx
• tnt
• SKIN (ANATOMY)
• sensitivity
• data analysis
• reactivities
• range finding
• public health
• ENVIRONMENTAL HEALTH

Subject Categories:

• Anatomy and Physiology
• Environmental Health and Safety

Distribution Statement:

APPROVED FOR PUBLIC RELEASE