The Function of NFAT3 in Ovarian Cancer Cell Quiescence and Chemotherapy Resistance
Technical Report,15 May 2015,15 Oct 2019
Magee-Womens Research Institute and Foundation Pittsburgh United States
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The majority of deaths from ovarian cancer are related to disease recurrence and the subsequent development of chemotherapy-resistant disease, which is inevitably fatal. Elucidating mechanisms of chemo resistance in ovarian cancer cells may identify critical therapeutic targets to prevent or treat relapsed ovarian cancer. One feature that might contribute to the chemotherapy resistance is quiescence. Quiescence promotes chemotherapy resistance of adult stem cells. Quiescence in the adult hair follicle stem cell is mediated by Nuclear Factor of Activated T cells-1 NFAT1. NFAT proteins are master transcriptional regulators that function in conjunction with the AP1 transcription factors c-Fos and c-Jun to regulate cellular stress responses NFATAP1 regulate the cell cycle via transcriptional down-regulation of the cyclin dependent kinasesCDK4CDK6. NFAT proteins also regulate protein synthesis via transcriptional control of ribosomal protein subunit expression. Interestingly, quiescent hematopoietic stem cells have reduced protein synthesis.
- Medicine and Medical Research
- Anatomy and Physiology