Accession Number:

AD1099261

Title:

Biomechanics of Blast TBI with Time-Resolved Consecutive Primary, Secondary, and Tertiary Loads

Descriptive Note:

Journal Article - Open Access

Corporate Author:

NAVAL RESEARCH LAB WASHINGTON DC WASHINGTON United States

Report Date:

2019-03-21

Pagination or Media Count:

11.0

Abstract:

Blast-induced traumatic brain injury bTBI has become a signature casualty of recent military operations. In spite of significant clinical and preclinical TBI research, current understanding of injury mechanisms and short- and long-term outcomes is limited. Mathematical models of bTBI biomechanics may help in better understanding of injury mechanisms and in the development of improved neuroprotective strategies. Until present, bTBI has been analyzed as a single event of a blast pressure wave propagating through the brain. In many bTBI events, the loads on the body and the head are spatially and temporarily distributed, involving the primary intracranial pressure wave, followed by the head rotation and then by head impact on the ground. In such cases, the brain microstructures may experience timespace distributed consecutive damage and recovery events. The paper presents a novel multiscale simulation framework that couples the bodybrain scale biomechanics with micro-scale mechanobiology to study the effects of micro-damage to neuro-axonal structures. Our results show that the micro-mechanical responses of neuro-axonal structures occur sequentially in time with damage and relaxation periods in different parts of the brain. A new integrated computational framework is described coupling the brain-scale biomechanics with micro-mechanical damage to axonal and synaptic structures.

Subject Categories:

  • Radiofrequency Wave Propagation
  • Medicine and Medical Research
  • Theoretical Mathematics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE